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Description

Indications and Dosage
Oral
Epilepsy
Adult: Initially, 25 mg at night for 1 wk, increased in increments of 25 or 50 mg at 1-2 wk interval until effective dose is reached. Doses >25 mg should be taken in 2 divided doses. Usual dose: 100 mg daily. Max: 500 mg daily.
Child: ≥6 yr Initially, 0.5-1 mg/kg at night for 1 wk, increased in increments of 0.5-1 mg/kg at 1-2 wk interval. Initial target dose: 100 mg (approx 2 mg/kg) daily in 2 divided doses.

Oral
Prophylaxis of migraine
Adult: Initially, 25 mg at night for 1 wk, increased in increments of 25 mg at wkly interval. Usual dose: 50-100 mg daily in 2 divided doses. Max: 200 mg daily.

Oral
Adjunct for seizures associated with the Lennox-Gastaut syndrome, Adjunct in epilepsy
Adult: Initially, 25-50 mg at night for 1 wk, increased in increments of 25 or 50 mg at 1-2 wk interval until effective dose is reached. Doses >25 mg should be taken in 2 divided doses. Usual dose: 200-400 mg daily.
Child: ≥2 yr Initially, 25 mg at night for 1 wk, increased in increments of 1-3 mg/kg at 1-2 wk interval until effective dose is reached. Doses >25 mg should be taken in 2 divided doses. Usual dose: Approx 5-9 mg/kg daily.