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Description

Indications and Dosage
Oral
Schizophrenia
Adult: As immediate-release/film-coated tab: Initially, 25 mg bid on day 1, followed by 50 mg bid on day 2, 100 mg bid on day 3 and 150 mg bid on day 4. Titrate dose according to response between 300-450 mg daily given in 2 divided doses from day 4 onwards. Max: 750 mg daily. As extended-release tab: 300 mg once daily on day 1, followed by 600 mg once daily on day 2. Adjust according to patient response between 400-800 mg daily. Usual dose: 600 mg once daily. Max: 800 mg daily.
Elderly: As immediate-release/film-coated tab: Slower rate of dose titration and lower daily therapeutic dose. As modified-release tab: Initially, 50 mg once daily, adjusted in increments of 50 mg according to response.

Oral
Acute manic episodes of bipolar disorder
Adult: As immediate-release/film-coated tab: 50 mg bid for day 1, followed by 100 mg bid for day 2 then 150 mg bid on day 3 and 200 mg bid on day 4. Adjust in increments up to 200 mg daily according to response. Usual dose: 400-800 mg daily in 2 divided doses. Max: 800 mg daily. As extended-release tab: 300 mg once daily on day 1, followed by 600 mg daily on day 2 adjusted according to response. Usual dose: 400-800 mg once daily.
Elderly: As immediate-release/film-coated tab: Slower rate of dose titration and lower daily therapeutic dose. As extended-release tab: Initially, 50 mg once daily, adjusted in increments of 50 mg according to response.

Oral
Depressive phase of bipolar disorder
Adult: As immediate-release/film-coated/extended-release tab: 50 mg once daily on day 1 to be taken at bedtime, followed by 100 mg once daily on day 2 then 200 mg once daily on day 3 and 300 mg once daily on day 4. Adjust according to patient response. Usual dose: 300 mg once daily. Max: 600 mg daily.
Elderly: As immediate-release tab/film-coated: Slower rate of dose titration and lower daily therapeutic dose.

Oral
Prophylaxis of bipolar disorder
Adult: As immediate-release tab/film-coated: Continue at the dose effective for treatment of bipolar disorder and adjust to lowest effective dose. Usual dose: 300-800 mg daily in 2 divided doses. As extended-release tab: Continue at the dose effective for treatment of bipolar disorder and adjust to lowest effective dose. Usual dose: 300-800 mg once daily.

Oral
Major depressive disorder
Adult: In combination with other drugs for major depression: As extended-release tab: 50 mg once daily for days 1 and 2, dose to be taken at bedtime, followed by 150 mg once daily for days 3 and 4 then adjusted according to response. Usual dose: 150-300 mg once daily.
Elderly: As extended-release tab: Initially, 50 mg once daily on days 1-3 then increased to 100 mg once daily on day 4 and 150 mg on day 8. Adjust in increments of 50 mg according to response, the lowest effective dose should be used. Usual dose: 50-300 mg once daily. 300 mg dose should not be reached prior to day 22 of treatment.